Cyclodextrin-Modified Polyethylenimine Polymers for Gene Delivery
Identifieur interne : 001F26 ( Main/Exploration ); précédent : 001F25; suivant : 001F27Cyclodextrin-Modified Polyethylenimine Polymers for Gene Delivery
Auteurs : Suzie H. Pun [États-Unis] ; Nathalie C. Bellocq [États-Unis] ; Aijie Liu [États-Unis] ; Greg Jensen [États-Unis] ; Todd Machemer [États-Unis] ; Erlinda Quijano [États-Unis] ; Thomas Schluep [États-Unis] ; Shufen Wen [États-Unis] ; Heidrun Engler [États-Unis] ; Jeremy Heidel [États-Unis] ; Mark E. Davis [États-Unis]Source :
- Bioconjugate Chemistry [ 1043-1802 ] ; 2004.
Abstract
Linear and branched poly(ethylenimines), lPEI and bPEI, respectively, grafted with β-cyclodextrin are prepared to give CD−lPEI and CD−bPEI, respectively, and are investigated as in vitro and in vivo nonviral gene delivery agents. The in vitro toxicity and transfection efficiency are sensitive to the level of cyclodextrin grafting. The cyclodextrin-containing polycations, when combined with adamantane−poly(ethylene glycol) (AD−PEG) conjugates, form particles that are stable at physiological salt concentrations. PEGylated CD−lPEI-based particles give in vitro gene expression equal to or greater than lPEI as measured by the percentage of EGFP expressing cells. Tail vein injections into mice of 120 μg of plasmid DNA formulated with CD−lPEI and AD−PEG do not reveal observable toxicities, and both nucleic acid accumulation and expression are observed in liver.
Url:
DOI: 10.1021/bc049891g
Affiliations:
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Delivery</title><author><name sortKey="Pun, Suzie H" sort="Pun, Suzie H" uniqKey="Pun S" first="Suzie H." last="Pun">Suzie H. Pun</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Insert Therapeutics Inc., 2585 Nina Street, Pasadena, California 91107, Canji, Inc., 3525 Johns Hopkins Court,San Diego, California 92121, and Chemical Engineering, California Institute of Technology,Pasadena</wicri:cityArea></affiliation><affiliation></affiliation><affiliation></affiliation></author><author><name sortKey="Bellocq, Nathalie C" sort="Bellocq, Nathalie C" uniqKey="Bellocq N" first="Nathalie C." last="Bellocq">Nathalie C. Bellocq</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Insert Therapeutics Inc., 2585 Nina Street, Pasadena, California 91107, Canji, Inc., 3525 Johns Hopkins Court,San Diego, California 92121, and Chemical Engineering, California Institute of Technology,Pasadena</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Liu, Aijie" sort="Liu, Aijie" uniqKey="Liu A" first="Aijie" last="Liu">Aijie Liu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Insert Therapeutics Inc., 2585 Nina Street, Pasadena, California 91107, Canji, Inc., 3525 Johns Hopkins Court,San Diego, California 92121, and Chemical Engineering, California Institute of Technology,Pasadena</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Jensen, Greg" sort="Jensen, Greg" uniqKey="Jensen G" first="Greg" last="Jensen">Greg Jensen</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Insert Therapeutics Inc., 2585 Nina Street, Pasadena, California 91107, Canji, Inc., 3525 Johns Hopkins Court,San Diego, California 92121, and Chemical Engineering, California Institute of Technology,Pasadena</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Machemer, Todd" sort="Machemer, Todd" uniqKey="Machemer T" first="Todd" last="Machemer">Todd Machemer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Insert Therapeutics Inc., 2585 Nina Street, Pasadena, California 91107, Canji, Inc., 3525 Johns Hopkins Court,San Diego, California 92121, and Chemical Engineering, California Institute of Technology,Pasadena</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Quijano, Erlinda" sort="Quijano, Erlinda" uniqKey="Quijano E" first="Erlinda" last="Quijano">Erlinda Quijano</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Insert Therapeutics Inc., 2585 Nina Street, Pasadena, California 91107, Canji, Inc., 3525 Johns Hopkins Court,San Diego, California 92121, and Chemical Engineering, California Institute of Technology,Pasadena</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Schluep, Thomas" sort="Schluep, Thomas" uniqKey="Schluep T" first="Thomas" last="Schluep">Thomas Schluep</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Insert Therapeutics Inc., 2585 Nina Street, Pasadena, California 91107, Canji, Inc., 3525 Johns Hopkins Court,San Diego, California 92121, and Chemical Engineering, California Institute of Technology,Pasadena</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Wen, Shufen" sort="Wen, Shufen" uniqKey="Wen S" first="Shufen" last="Wen">Shufen Wen</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Insert Therapeutics Inc., 2585 Nina Street, Pasadena, California 91107, Canji, Inc., 3525 Johns Hopkins Court,San Diego, California 92121, and Chemical Engineering, California Institute of Technology,Pasadena</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Engler, Heidrun" sort="Engler, Heidrun" uniqKey="Engler H" first="Heidrun" last="Engler">Heidrun Engler</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Insert Therapeutics Inc., 2585 Nina Street, Pasadena, California 91107, Canji, Inc., 3525 Johns Hopkins Court,San Diego, California 92121, and Chemical Engineering, California Institute of Technology,Pasadena</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Heidel, Jeremy" sort="Heidel, Jeremy" uniqKey="Heidel J" first="Jeremy" last="Heidel">Jeremy Heidel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Insert Therapeutics Inc., 2585 Nina Street, Pasadena, California 91107, Canji, Inc., 3525 Johns Hopkins Court,San Diego, California 92121, and Chemical Engineering, California Institute of Technology,Pasadena</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Davis, Mark E" sort="Davis, Mark E" uniqKey="Davis M" first="Mark E." last="Davis">Mark E. Davis</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Insert Therapeutics Inc., 2585 Nina Street, Pasadena, California 91107, Canji, Inc., 3525 Johns Hopkins Court,San Diego, California 92121, and Chemical Engineering, California Institute of Technology,Pasadena</wicri:cityArea></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Bioconjugate Chemistry</title><title level="j" type="abbrev">Bioconjugate Chem.</title><idno type="ISSN">1043-1802</idno><idno type="eISSN">1520-4812</idno><imprint><publisher>American Chemical Society</publisher><date type="e-published" when="2004-06-29">2004</date><date when="2004-07-21">2004</date><biblScope unit="vol">15</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="831">831</biblScope><biblScope unit="page" to="840">840</biblScope></imprint><idno type="ISSN">1043-1802</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1043-1802</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Linear and branched poly(ethylenimines), lPEI and bPEI, respectively, grafted with β-cyclodextrin are prepared to give CD−lPEI and CD−bPEI, respectively, and are investigated as in vitro and in vivo nonviral gene delivery agents. The in vitro toxicity and transfection efficiency are sensitive to the level of cyclodextrin grafting. The cyclodextrin-containing polycations, when combined with adamantane−poly(ethylene glycol) (AD−PEG) conjugates, form particles that are stable at physiological salt concentrations. PEGylated CD−lPEI-based particles give in vitro gene expression equal to or greater than lPEI as measured by the percentage of EGFP expressing cells. Tail vein injections into mice of 120 μg of plasmid DNA formulated with CD−lPEI and AD−PEG do not reveal observable toxicities, and both nucleic acid accumulation and expression are observed in liver.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Pun, Suzie H" sort="Pun, Suzie H" uniqKey="Pun S" first="Suzie H." last="Pun">Suzie H. Pun</name></region><name sortKey="Bellocq, Nathalie C" sort="Bellocq, Nathalie C" uniqKey="Bellocq N" first="Nathalie C." last="Bellocq">Nathalie C. Bellocq</name><name sortKey="Davis, Mark E" sort="Davis, Mark E" uniqKey="Davis M" first="Mark E." last="Davis">Mark E. Davis</name><name sortKey="Davis, Mark E" sort="Davis, Mark E" uniqKey="Davis M" first="Mark E." last="Davis">Mark E. Davis</name><name sortKey="Engler, Heidrun" sort="Engler, Heidrun" uniqKey="Engler H" first="Heidrun" last="Engler">Heidrun Engler</name><name sortKey="Heidel, Jeremy" sort="Heidel, Jeremy" uniqKey="Heidel J" first="Jeremy" last="Heidel">Jeremy Heidel</name><name sortKey="Jensen, Greg" sort="Jensen, Greg" uniqKey="Jensen G" first="Greg" last="Jensen">Greg Jensen</name><name sortKey="Liu, Aijie" sort="Liu, Aijie" uniqKey="Liu A" first="Aijie" last="Liu">Aijie Liu</name><name sortKey="Machemer, Todd" sort="Machemer, Todd" uniqKey="Machemer T" first="Todd" last="Machemer">Todd Machemer</name><name sortKey="Quijano, Erlinda" sort="Quijano, Erlinda" uniqKey="Quijano E" first="Erlinda" last="Quijano">Erlinda Quijano</name><name sortKey="Schluep, Thomas" sort="Schluep, Thomas" uniqKey="Schluep T" first="Thomas" last="Schluep">Thomas Schluep</name><name sortKey="Wen, Shufen" sort="Wen, Shufen" uniqKey="Wen S" first="Shufen" last="Wen">Shufen Wen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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